pI: 6.8967 |
Length (AA): 1702 |
MW (Da): 193745 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 10 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
108 | 234 | 3frx (A) | 18 | 140 | 24.00 | 0.089 | 0.21 | 0.222218 | 0.53 |
143 | 507 | 5gxi (A) | 319 | 710 | 21.00 | 0.0053 | 0.99 | 0.380154 | 0.43 |
162 | 426 | 4j87 (A) | 4 | 310 | 25.00 | 0.0000002 | 1 | 0.320399 | 0.25 |
185 | 564 | 3sfz (A) | 818 | 1213 | 27.00 | 0.0000000000069 | 1 | 0.168967 | 1.54 |
191 | 519 | 3mkq (A) | 3 | 310 | 12.00 | 0 | 0.94 | 0.333502 | -0.3 |
199 | 233 | 4u7a (A) | 435 | 469 | 40.00 | 0.52 | 0.45 | 0.410264 | 0.45 |
447 | 519 | 4i79 (A) | 181 | 261 | 38.00 | 0.0096 | 0.78 | 0.336591 | 0.54 |
1097 | 1209 | 3qzt (A) | 68 | 169 | 32.00 | 0.0000024 | 1 | 0.472092 | -0.96 |
1109 | 1213 | 4cos (A) | 150 | 253 | 23.00 | 0.000000000055 | 1 | 0.564292 | -1.93 |
1111 | 1216 | 5mlj (A) | 731 | 836 | 26.00 | 0 | 1 | 0.56888 | -1.67 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129383)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G49430 | WD40/YVTN repeat and Bromo-WDR9-I-like domain-containing protein |
Arabidopsis thaliana | AT2G47410 | WD40 domain-containing protein |
Brugia malayi | Bm1_28055 | Bromodomain containing protein |
Dictyostelium discoideum | DDB_G0285837 | BRWD group protein |
Drosophila melanogaster | Dmel_CG31132 | CG31132 gene product from transcript CG31132-RA |
Entamoeba histolytica | EHI_176990 | hypothetical protein |
Homo sapiens | ENSG00000185658 | bromodomain and WD repeat domain containing 1 |
Homo sapiens | ENSG00000165288 | bromodomain and WD repeat domain containing 3 |
Homo sapiens | ENSG00000146247 | pleckstrin homology domain interacting protein |
Loa Loa (eye worm) | LOAG_04870 | hypothetical protein |
Mus musculus | ENSMUSG00000022914 | bromodomain and WD repeat domain containing 1 |
Mus musculus | ENSMUSG00000032253 | pleckstrin homology domain interacting protein |
Mus musculus | ENSMUSG00000063663 | bromodomain and WD repeat domain containing 3 |
Oryza sativa | 9268022 | Os03g0306301 |
Onchocerca volvulus | OVOC12900 |
|
Onchocerca volvulus | OVOC1496 |
|
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.